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InPlace™ and EasyPack™ Columns

Precise. Reproducible. Sustainable.

Process-scale Low Pressure Liquid Chromatography (LPLC) Columns for GMP Manufacturing

200 to 2000 mm inner diameter (i.d.)

InPlace™ and EasyPack™ Columns provide reliable and consistent packing with automated precision-driven axial compression technology.

Axial compression column packing is directly scalable from laboratory to commercial manufacturing ensuring reproducible column performance at any diameter from 20-200cm.

Packing methods can easily be scaled up or down with simplified slurry transfer and bed consolidation protocols for predictable first-time right packing. First Time. Every Time.

 

Minimum Downtime. Maximum Confidence.

VERDOT experts are available worldwide to assist with onsite column packing and provide solutions for unique procedural and environmental challenges. With innovative packing techniques, even the most challenging chromatography resins can be packed into a well-distributed and stable bed.

Take advantage of our on-site packing support to ensure you receive exceptional user experience with VERDOT columns.

 

Both columns offer:

  • Scalable column design from 200 mm – 2000 mm (2 m), so you can scale with confidence.
  • Simplify workflows on the VERDOT control console with automated column packing and unpacking. A single control console supports multiple column configurations.
  • Unique frit and flow distributor design provides optimal and uniform flow distribution even for hard-to-pack and incompressible resins (Mobile Phase Distribution Technical Note)
  • Compact and sustainable: 50% lighter and 17% shorter than comparable columns
  • Unpacking and repacking with slurry sparging (aka: air assistance) for reduced buffer usage. Repack in place can be performed in 1-4 hours.
  • Column design ensures ease of cleaning and sanitization
  • Hoist-free maintenance with the VERDOT column lifter
  • All resins welcome. Extensive technical library on packing parameters for every type of commercial chromatography resin including hard-to-pack and incompressible resins/hydroxyapatite
  • Onsite packing support and training to ensure an exceptional user experience. Minimum downtime. Maximum Confidence.
  • Comprehensive documentation packages for IQ/OQ and regulatory submissions

Our sustainability promise

InPlace™ Columns

EasyPack™ Columns

Application

Small to large workflows

Small to large workflows

Motorized Axial Compression

Yes

Optional

Standard Diameters

200-2000 mm

200-2000 mm

Custom Diameters

Yes

No

Standard Tube Heights

600 or 900 mm

600 or 900 mm

Custom Tube Heights

Yes

No

Slurry Valves

On side of column

N/A

Slurry Transfer

Syringe-style slurry transfer for minimal resin loss and mechanical shear

Open column design

Packing

Fully automated

Semi-automated

Unpacking

Fully or semi-automated

Less than 2.5 CV of buffer

Semi-automated

Tilt Mechanism

Yes; for air removal

Optional

Operating Pressure

Up to 6 bar

Up to 6 bar

Frit Pore Size

Standard: 20 µm nominal

Custom: 2-50 µm

Standard: 20 µm nominal

Custom: 2-50 µm

Tube Materials of Construction

Acrylic

Stainless steel

Borosilicate glass (up to 450 mm i.d.)

Acrylic

Stainless steel

Borosilicate glass (up to 450 mm i.d.)

Wetted Parts Materials of Construction

USP class VI, 21 CFR 177 and animal-free origin or in compliance with EMEA/410

USP class VI, 21 CFR 177 and animal-free origin or in compliance with EMEA/410

If you have specialized requirements, we design custom columns for unique applications tailored to your specifications.  Your Process.  Your Way.

 

Contact VERDOT now to upgrade your column packing experience!