InPlace™ and EasyPack™ Columns

Process-scale Low Pressure Liquid Chromatography (LPLC) Columns for GMP Manufacturing

200 to 2000 mm inner diameter (i.d.)

InPlace™ and EasyPack™ Columns provide reliable and consistent packing with automated precision-driven axial compression technology.

Axial compression column packing is directly scalable from laboratory to commercial manufacturing ensuring reproducible column performance at any diameter from 20-200cm.

Packing methods can easily be scaled up or down with simplified slurry transfer and bed consolidation protocols for predictable first-time right packing. First Time. Every Time.

Minimum Downtime. Maximum Confidence.

VERDOT experts are available worldwide to assist with onsite column packing and provide solutions for unique procedural and environmental challenges. With innovative packing techniques, even the most challenging chromatography resins can be packed into a well-distributed and stable bed.

Take advantage of our on-site packing support to ensure you receive exceptional user experience with VERDOT columns.

Both columns offer:

Scalable column design from 200 mm – 2000 mm (2 m), so you can scale with confidence.
Simplify workflows on the VERDOT control console with automated column packing and unpacking. A single control console supports multiple column configurations.
Unique frit and flow distributor design provides optimal and uniform flow distribution even for hard-to-pack and incompressible resins (Mobile Phase Distribution Technical Note)
Compact and sustainable: 50% lighter and 17% shorter than comparable columns
Unpacking and repacking with slurry sparging (aka: air assistance) for reduced buffer usage. Repack in place can be performed in 1-4 hours.
Column design ensures ease of cleaning and sanitization
Hoist-free maintenance with the VERDOT column lifter
All resins welcome. Extensive technical library on packing parameters for every type of commercial chromatography resin including hard-to-pack and incompressible resins/hydroxyapatite
Onsite packing support and training to ensure an exceptional user experience. Minimum downtime. Maximum Confidence.
Comprehensive documentation packages for IQ/OQ and regulatory submissions

Our sustainability promise

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	InPlace™ Columns	EasyPack™ Columns
Application	Small to large workflows	Small to large workflows
Motorized Axial Compression	Yes	Optional
Standard Diameters	200-2000 mm	200-2000 mm
Custom Diameters	Yes	No
Standard Tube Heights	600 or 900 mm	600 or 900 mm
Custom Tube Heights	Yes	No
Slurry Valves	On side of column	N/A
Slurry Transfer	Syringe-style slurry transfer for minimal resin loss and mechanical shear	Open column design
Packing	Fully automated	Semi-automated
Unpacking	Fully or semi-automated Less than 2.5 CV of buffer	Semi-automated
Tilt Mechanism	Yes; for air removal	Optional
Operating Pressure	Up to 6 bar	Up to 6 bar
Frit Pore Size	Standard: 20 µm nominal Custom: 2-50 µm	Standard: 20 µm nominal Custom: 2-50 µm
Tube Materials of Construction	Acrylic Stainless steel Borosilicate glass (up to 450 mm i.d.)	Acrylic Stainless steel Borosilicate glass (up to 450 mm i.d.)
Wetted Parts Materials of Construction	USP class VI, 21 CFR 177 and animal-free origin or in compliance with EMEA/410	USP class VI, 21 CFR 177 and animal-free origin or in compliance with EMEA/410